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It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat

Importantly, commonly used in vitro BBB models, such as transwell systems and endothelial cell lines including RBE4, bEnd.3, and hCMEC/D3 monolayers, have important limitations, as they may overpredict permeability and do not fully recapitulate key in vivo BBB features, including physiological shear stress and multicellular neurovascular architecture (Katt and Shusta, 2020)

(2) Absorption of cyanocobalamin, coenzyme B12, methylcobalamin, and hydroxocobalamin at different dose levels (3) Intestinal absorption and concurrent chemical changes of methylcobalamin (4) NIH Office of Dietary Supplements: Vitamin B12 (5) B Vitamins: Chemistry, Metabolism, and Health Effects Disclaimer The statements in this article have not been evaluated by the Food and Drug Administration